Frequency and Type-distribution of Human Papillomavirus from Paraffin-embedded Blocks of High Grade Cervical Intraepithelial Neoplasia Lesions

Cervical cancer is the most common cause of cancer death in Thai woman. The incidence of new cases per years is 9999 and mortality is about 50% (Munoz, 2000). The etiology of this cancer is Human papillomavirus (HPV). High grade cervical lesion is precancerous lesion of cervical cancer that has abnormal tissue related to persistent HPV infection and can be developed to cervical cancer (Walboomers et al., 1999; Munoz, 2000). In recently more than 200 type of HPV have been report (Dowhanick et al., 1995; Villiers et al., 2004; Lurchachaiwong et al., 2009) and classified influence by carcinogenesis potential and about 40 types are correlated anogenital infection. Approximately 15 HPV type associate with high grade epithelial cervical neoplasia, invasive cervical and other anogenital cancer have been categorized as high-risk types such as HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82, whereas the HPV types which found primarily in genital wart or non-malignant lesion were designed as low-risk types such as HPV 6, 11, 40, 42, 43, 44, 54, 61, 72, 81, 83, 84; (IARC, 1995; Zur, 2002; Bharti